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This research aims to analyze the detailed structural changes in mitochondria of SH-SY5Y cells induced by retinoic acid treatment.

From lamellar and storage bodies to mitophagy: a comprehensive view of mitochondrial ultrastructure in differentiated SH-SY5Y cells

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This research aims to analyze the detailed structural changes in mitochondria of SH-SY5Y cells induced by retinoic acid treatment.
SH-SY5Y cells were treated with retinoic acid for differentiation and analyzed using transmission and scanning electron microscopy.
X-ray spectroscopy microanalysis was performed to examine mitochondrial ultrastructure.
Observations focused on mitochondrial anomalies and their relationship to the endoplasmic reticulum network.
Mitochondria in RA-treated cells exhibited prominent structural anomalies, affecting one-fifth of the observed profiles.
Defective fine structures resembling 'lamellar bodies' and associated mitophagy were identified.
Findings indicated parallels with mitochondrial changes observed in neurodegenerative diseases, such as Parkinson's.

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Randomized trial observes mitochondrial structural changes in neuroblastoma cells, suggesting implications for neurodegenerative research.

Gilloteaux et al. (2026) studied this question.

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Randomized trial observes mitochondrial structural changes in neuroblastoma cells, suggesting implications for neurodegenerative research.