The aim of the present study is to investigate the effects of diallyl disulfide (DADS),an active compound of garlic, on certain serum biochemical and oxidative stressparameters in colon cancer induced by azoxymethane (AOM) in rats. The rats weredivided into 5 groups: Control, AOM, DADS, AOM+DADS and corn oil. AOM-treated groups received 15 mg/kg sc AOM injections (twice at one-week intervals),while DADS-treated groups received 50 mg/kg DADS via gavage 5 days a week atthe end of the 15th week. The corn oil group received 1 ml/kg corn oil via gavage5 days a week (for 3 weeks) at the end of the 15th week of the study. Total proteinand albumin (p<0.05) levels were higher in the DADS group than in the AOMgroup. ALP activity decreased in the DADS and AOM+DADS groups; whereas, ALTactivity increased in the AOM group (p<0.05). Additionally, cholesterol and HDLlevels lowered in the AOM and AOM+DADS groups (p<0.05). ROS concentrationwas significantly higher in the AOM group compared to the other groups (p<0.05),while GPx levels were low. Serum magnesium concentration was lower in theAOM+DADS group compared to the control group (p<0.05) and this decrease wasaccompanied by urea levels in both the AOM+DADS and DADS groups (p<0.05).Compared to the control group, iron levels were high in the DADS group, whilechloride levels were high in the DADS, AOM+DADS and corn oil groups (p<0.05).In conclusion, the decreases in serum cholesterol and HDL levels, particularly in theAOM group, supported the notion that these parameters could be important cancerbiomarkers in cancer cases. Furthermore, the changes in chloride and iron level sacross groups were striking and it was concluded that many biochemical parameterscould be identified as new biomarkers in colon cancer through investigation of thetherapeutic efficacy of DADS.
Turan et al. (Mon,) studied this question.