Too little or too much sleep is linked to faster ageing throughout the body

doi:10.1038/d41586-026-01564-y

May 20, 2026NatureOpen Access

Too little or too much sleep is linked to faster ageing throughout the body

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Key Points

This research investigates the relationship between sleep duration and biological ageing across various organ systems.
Multimodal analysis of sleep duration and biological ageing across different organ systems.
Assessment of the relationship between sleep extremes and late-life depression.
Evaluation of the U-shaped association between sleep duration and organ ageing.
Both insufficient and excessive sleep are linked to accelerated organ ageing.
The analysis identifies the U-shaped relationship between sleep duration and biological ageing.
Biological ageing plays a significant role in the connection between sleep extremes and late-life depression.

Implication

Multimodal analysis reveals sleep extremes accelerate biological ageing and influence late-life depression.

Abstract

A multimodal analysis reveals a ‘U-shaped’ association between sleep duration and biological ageing across various organ systems, with too much or not enough sleep being linked with accelerated organ ageing. The study also shows that biological ageing differentially mediates the relationship between extremes in sleep duration and late-life depression.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a0ff3ecd674f7c03778cd3b https://doi.org/10.1038/d41586-026-01564-y

View Full Paper

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Too little or too much sleep is linked to faster ageing throughout the body

Key Points

Implication

Abstract

Discussion

Cite This Study

Too little or too much sleep is linked to faster ageing throughout the body

Key Points

Implication

Abstract

Discussion

Cite This Study

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