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May 22, 2026PathogensOpen Access

Association Between Serum Phosphorus and 28-Day Mortality in Patients with Bloodstream Infection: Potential Prognostic Implication Beyond Renal Function and Clinical Severity

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Authors

NPNingjing PuJXJuan XiongYSYueshan Sun

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Overview

Retrospective cohort study finds higher 28-day mortality in bloodstream infection patients with hyperphosphatemia, suggesting prognostic implications.

Key Points

  • This study investigates the link between serum phosphorus levels and 28-day mortality in bloodstream infection patients, assessing whether this relationship holds after adjusting for other factors.
  • Retrospective cohort study of 214 patients with bloodstream infection.
  • Patients were categorized into hyperphosphatemia (≥2.2 mmol/L) and control (<2.2 mmol/L) groups.
  • Multivariate regression and spline analysis were applied to explore the mortality association.
  • 28-day mortality was higher in the hyperphosphatemia group (80.0% vs. 39.7%, p = 0.005).
  • Hyperphosphatemia was significantly linked to higher mortality (OR = 4.46, 95% CI: 1.36–18.54, p = 0.012) after adjustments.
  • Every 0.5 mmol/L rise in serum phosphorus increased mortality odds by 34% (OR = 1.34, 95% CI: 1.07–1.74, p = 0.01).

Cite This Study

Pu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ecd674f7c03778cebdhttps://doi.org/10.3390/pathogens15050553
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the association between serum phosphate levels and mortality in patients hospitalized with infectious diseases: a nationwide study2024 · 4 citations
  2. 2Effect of early serum phosphate disorder on in-hospital and 28-day mortality in sepsis patients: a retrospective study based on MIMIC-IV database2024 · 8 citations
  3. 3Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta‐analysis2026
  4. 4Association Between the Serum Phosphate Levels and Hospital Mortality as Well as 90-Day Mortality Among Critically Ill Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study2024 · 3 citations
  5. 5Phosphate Supplementation and Target Serum Levels in Sepsis: Impact on Patient Outcomes2024