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January 1, 2026RSC AdvancesOpen Access

Iodine-catalyzed green and efficient synthesis of secondary and tert -esters of N -acetyl-protected amino acids

Ghazala Razaq Abbasi Muhammad Arfan Muhammad Fahad Ehsan Aamal Rehman Imran Shakir Muhammad Latif

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Key Points

The aim is to explore a green and efficient method for synthesizing secondary and tert-esters of N-acetyl-protected amino acids.
Utilized iodine as a catalyst for the esterification process.
Focused on amino acid derivatives, specifically N-acetyl-protected variants.
Successfully achieved the esterification of N-acetyl-protected amino acids with high efficiency.
Demonstrated the potential for an environmentally friendly synthesis method.

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Implication

Demonstrates efficient esterification of amino acids, suggesting a significant advancement in peptide synthesis.

Abstract

Esterification of amino acids: a key transformation in synthetic peptide chemistry.

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Cite This Study

Abbasi et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff43fd674f7c03778d74b https://doi.org/10.1039/d6ra03408j

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