Key result
FDG PET/CT detects an asymptomatic right ventricular metastasis in recurrent leiomyosarcoma.
Why the study?
Cardiac metastasis from soft tissue sarcomas is exceptionally rare and often underdiagnosed due to nonspecific clinical manifestations.
Case Report (n=1)
No
FDG PET/CT is useful for detecting occult and atypical metastatic sites, such as cardiac metastasis, in patients with leiomyosarcoma.
Cardiac metastasis warrants consideration in refractory LMS despite nonspecific symptoms; leaves open optimal surveillance and management strategies.
Leiomyosarcoma (LMS) is a malignant mesenchymal tumour known for its aggressive clinical behaviour and potential for distant metastasis. Cardiac metastasis from soft tissue sarcomas is exceptionally rare and often underdiagnosed due to nonspecific clinical manifestations. We report a case of a 45-year-old male with recurrent high-grade leiomyosarcoma of the left thigh, previously treated with surgery and multiple lines of chemotherapy, who presented with progressive disease despite treatment. FDG PET/CT during disease surveillance identified a suspicious FDG-avid intraventricular soft tissue lesion in the right ventricle, which was confirmed on echocardiography, consistent with cardiac metastasis. This case underscores the utility of FDG PET/CT in detecting occult and atypical metastatic sites, which may significantly impact patient management and prognosis. We also provide a concise literature review of cardiac metastases in LMS and the evolving role of advanced imaging in such complex scenarios.
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Edamadaka et al. (2026) conducted a case report in Recurrent Leiomyosarcoma (n=1). FDG PET/CT was evaluated. FDG PET/CT successfully identified an occult, asymptomatic cardiac metastasis in the right ventricle of a patient with recurrent leiomyosarcoma.
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