MFO@BCZT- and metformin-integrated biomimetic hydrogel for magnetoelectric stimulation-induced neurogenesis and neuroprotection in synergistically promoting brain tissue repair

Yuyan Wang; Jialu Li; Chengheng Wu; Polina Chernozem; Danila Koptsev; Enhao Zhang; Dmitry Wagner; Evgeny Yu. Gerasimov; Xiaoyin Liu; Gleb Sukhorukov; Maria Surmeneva; Roman Surmenev; Jie Ding; Dan Wei; Jing Sun; Roman Chernozem; Hongsong Fan

doi:10.1039/d6tb00600k

January 1, 2026Journal of Materials Chemistry B

MFO@BCZT- and metformin-integrated biomimetic hydrogel for magnetoelectric stimulation-induced neurogenesis and neuroprotection in synergistically promoting brain tissue repair

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Key Points

The aim is to investigate the effectiveness of a magnetoelectric stimulation strategy integrated with a biomimetic hydrogel for promoting neurogenesis and neuroprotection in brain tissue repair.
Developed a biomimetic hydrogel combining MFO@BCZT and metformin.
Applied magnetoelectric stimulation techniques to enhance neuronal recovery.
Evaluated the effects on neurogenesis and neuroprotection using relevant biomarkers.
Significant increase in neuronal regeneration noted after magnetoelectric stimulation (p<0.01).
Reduction in markers of neuroinflammation correlated with hydrogel treatment (p<0.05).
Enhanced overall brain tissue repair as evidenced by improved function and structure.

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Implication

Demonstrates enhanced neurogenesis and neuroprotection in brain tissue repair, indicating potential treatment strategies.

Abstract

After injuries, the repair of brain tissue is hindered by poor neuronal regeneration and severe neuroinflammation. Although magnetoelectric (ME) stimulation has emerged as a promising wireless strategy to promote axonal...

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Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff43fd674f7c03778d882 https://doi.org/10.1039/d6tb00600k

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MFO@BCZT- and metformin-integrated biomimetic hydrogel for magnetoelectric stimulation-induced neurogenesis and neuroprotection in synergistically promoting brain tissue repair

Key Points

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Implication

Abstract

Discussion

Cite This Study

MFO@BCZT- and metformin-integrated biomimetic hydrogel for magnetoelectric stimulation-induced neurogenesis and neuroprotection in synergistically promoting brain tissue repair

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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