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May 22, 2026Chemical ReviewsOpen Access

Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease

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Authors

CSCharles R. SandersBCBruce CarterMWMason C. Wilkinson

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Overview

Exploratory analysis highlights PMP22's structure and function in Charcot-Marie-Tooth disease, suggesting therapeutic interventions.

Key Points

  • This research aims to investigate the role of PMP22 in the mechanisms underlying Charcot-Marie-Tooth disease (CMT).
  • Explored the structure and functions of PMP22
  • Examined the trafficking of PMP22 in Schwann cells
  • Discussed potential therapeutic interventions for CMT.
  • PMP22 overexpression during myelination induces proteostasis stress
  • Wild type allele of PMP22 contributes significantly to CMT1A
  • Structural variations in PMP22 correlate with different CMT subtypes.

Cite This Study

Sanders et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff452d674f7c03778da33https://doi.org/10.1021/acs.chemrev.6c00096
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Myelin Dysfunction in the Most Common Inherited Peripheral Neuropathies – CMT1A and HNPP2024
  2. 2Peripheral myelin protein 22 p.Tll8M point mutation in a family with no clinical phenotypes of Charcot-Marie-Tooth disease2025
  3. 3Hereditary neuropathies caused by mutations in the gene encoding peripheral myelin protein 222025
  4. 4Delayed Genetic Diagnosis of a Rare Presentation of Overlapping Peripheral Myelin Protein 22 (PMP22) Neuropathies2026
  5. 5P.062 Normal NCS in 42-year-old man with PMP22 duplication2024