The mechanoactivated transient receptor potential vanilloid type 4 (TRPV4) channel is expressed in distal tubule segments, where it controls flow-dependent K + transport. Global TRPV4 deficiency causes impaired adaptation to variations in dietary K + intake. Here, we demonstrate that renal tubule-specific TRPV4 deletion is sufficient to recapitulate the phenotype by causing antikaliuresis and higher plasma K + levels in both states of K + load and deficiency.
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Stavniichuk et al. (2023) studied this question.