Key result
Fluid shear stress causes vascular endothelial cells to elongate, align with flow direction, transiently increase fluid-phase endocytosis, and produce oriented actin and myosin filaments.
Why the study?
Does fluid shear stress alter the structure and function of living vascular endothelial cells?
Does fluid shear stress alter the structure and function of living vascular endothelial cells?
Fluid shear stress directly modulates the structural alignment, cytoskeletal organization, and functional endocytosis of vascular endothelial cells.
Informs endothelial mechanobiology models; leaves open translation to human vascular disease.
Shear stress produced by a flowing fluid has been found to cause changes in the structure and function of vascular endothelial cells. They tend to become elongated and aligned with the direction of flow. They respond to changes in fluid shear stress (either from low shear to high shear or vice versa) by transiently increasing fluid-phase endocytosis. And they are capable of producing intracellular actin and myosin filaments that are oriented in the flow direction.
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C. F. Dewey (1984) studied Vascular endothelial cells. Fluid shear stress was evaluated on Changes in structure and function of vascular endothelial cells. Fluid shear stress causes vascular endothelial cells to elongate, align with flow direction, transiently increase fluid-phase endocytosis, and produce oriented actin and myosin filaments.
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