Why the study?
Cardiac toxic effects of tegafur (S-1) are extremely rare, and there have been no previous reports on this issue.
Does tegafur cause acute coronary syndrome in patients with colon cancer?
Does tegafur cause acute coronary syndrome in patients with colon cancer?
Answers are grounded in this paper and cite their sources.
Tegafur (S-1) may cause acute coronary syndrome, highlighting the need for real-time cardiac monitoring during administration.
BACKGROUND: Cardiac toxic effect of tegafur (S-1) is extremely rare, and there has been no report on this issue so far. CASE SUMMARY: We herein report a typical case of single S-1 administration after radical operation for colon cancer. The patient had no background or medical history of acute coronary syndrome (ACS), and only aortic and coronary atherosclerosis was revealed by computed tomography (CT) before surgery. He complained of sternum pain during the fifth cycle of S-1 treatment. Electrocardiogram (ECG) and serum cardiac marker cardiac troponin T (cTnT) strongly suggested ACS, which was possibly caused by S-1 cardiotoxicity. CONCLUSION: Monitoring protocols based on ECG, CT, and cTnT should be performed in real time to evaluate cardiac function during S-1 administration.
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Zhang et al. (2019) studied this question.
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