Why the study?
Do patients with hypertriglyceridemia (types IIB and IV HLP) exhibit greater insulin resistance and glucose intolerance compared to normal subjects and hypercholesterolemic patients (type IIA HLP)?
Population
Normal volunteer subjects and patients with types IIA, IIB, and IV hyperlipoproteinemia (HLP)
Comparison
Oral glucose, mixed meals, and continuous… vs Normal subjects and patients with type IIA HLP
Design
Cross-sectional
Authors
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Supports hypertriglyceridemia–insulin resistance link in cross-sectional data; leaves open causality and clinical relevance.
Do patients with hypertriglyceridemia (types IIB and IV HLP) exhibit greater insulin resistance and glucose intolerance compared to normal subjects and hypercholesterolemic patients (type IIA HLP)?
Patients with hypertriglyceridemia are insulin resistant, glucose intolerant, and hyperinsulinemic, whereas hypercholesterolemic patients with normal triglycerides do not exhibit these abnormalities.
Sheu et al. (1993) studied this question.
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