Why the study?
Does local administration of abciximab resolve occlusive coronary thrombus refractory to systemic thrombolysis and conventional angioplasty?
Does local administration of abciximab resolve occlusive coronary thrombus refractory to systemic thrombolysis and conventional angioplasty?
Local delivery of abciximab may be effective for resolving refractory occlusive coronary thrombus during PTCA.
Local abciximab may aid refractory thrombus resolution; hypothesis-generating and requires prospective trials before adoption.
Treatment of intracoronary thrombus poses difficult problems and may result in severe complications. We used a local delivery catheter (InfusaSleeve, LocalMed, Palo Alto, CA) to treat an occlusive coronary thrombus that was refractory to systemic thrombolysis and conventional angioplasty. After local administration of 10 mg of abciximab with this catheter there was successful resolution of coronary thrombus and vessel recanalization. Cathet. Cardiovasc. Intervent. 48:211-213, 1999.
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Bartorelli et al. (1999) studied this question.
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