Key result
ECG abnormalities and risk scores fail to predict 5-year MACE in children with HCM.
Why the study?
An ECG risk score has been suggested for risk stratification in childhood hypertrophic cardiomyopathy, but has not been independently validated.
Does baseline ECG phenotype or ECG risk score predict 5-year sudden cardiac death risk in childhood hypertrophic cardiomyopathy?
Population
356 childhood HCM patients with a mean age of 10.1 years
Comparison
Baseline ECG phenotypes and ECG risk score for predicting arrhythmic events
Design
Retrospective, multi-centre international cohort study
Follow-up
Median 3.9 years
Authors
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Baseline ECG lacks utility for arrhythmic risk stratification in childhood HCM; leaves open identification of reliable predictors in prospective cohorts.
Cohort (n=356)
Yes
Does baseline ECG phenotype or ECG risk score predict 5-year sudden cardiac death risk in childhood hypertrophic cardiomyopathy?
Effect estimate: HR 2.07 (95% CI 0.77-5.60)
p-value: p=0.142
Baseline ECG characteristics and a previously described ECG risk score have limited utility in predicting 5-year sudden cardiac death risk in childhood hypertrophic cardiomyopathy.
Norrish et al. (2021) conducted a cohort in Childhood hypertrophic cardiomyopathy (n=356). ECG risk score >5 vs. ECG risk score ≤5 was evaluated on 5-year major arrhythmic cardiac event (MACE) (HR 2.07, 95% CI 0.77-5.60, p=0.142). In children with hypertrophic cardiomyopathy, neither individual electrocardiographic abnormalities nor a composite ECG risk score >5 were significantly associated with 5-year risk of major arrhythmic cardiac events.
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