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March 11, 2026iScience2 citationsOpen Access

Stimulation to secrete insulin induces pancreatic β-cell dysfunction through Tfe3 activation

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YAYuki AidaYokohama City University Medical CenterNKNozomu KadotaYokohama City University Medical CenterMTMimi TakahashiYokohama City University Medical Center

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Abstract

and other GSIS-related genes and suppresses the enhancer activity. Thus, stimulation to secrete insulin alters transcriptional program in β-cells toward dysfunction through Tfe3 activation.

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Cite This Study

Aida et al. (2026) studied this question.

synapsesocial.com/papers/6a1046e764e8141cd2602967https://doi.org/10.1016/j.isci.2026.115312
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