Key result
Indomethacin pretreatment (1 mg/kg) did not alter the renal blood flow and vascular conductance responses to endothelin-1 (250 ng/kg) in conscious lambs at 1-2 or 6 weeks of age.
Why the study?
Does indomethacin pretreatment alter the renal haemodynamic effects of endothelin-1 in conscious lambs?
Population
Conscious, chronically instrumented lambs at 1-2 weeks of age and 6 weeks of age
Comparison
Pretreatment with 1 mg/kg indomethacin followed… vs Pretreatment with vehicle followed by…
Design
Preclinical
Follow-up
5 minutes after injection
Authors
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Indomethacin does not modify ET-1 renal effects in developing lambs; hypothesis-generating for prostaglandin modulation in other models or species.
Does indomethacin pretreatment alter the renal haemodynamic effects of endothelin-1 in conscious lambs?
Endogenously produced prostaglandins do not appear to modulate the renal haemodynamic effects of endothelin-1 in conscious lambs during postnatal maturation.
Ebenezar et al. (2010) studied Healthy conscious lambs (postnatal maturation) (n=21). Indomethacin and Endothelin-1 (ET-1) vs. Vehicle was evaluated on Renal blood flow (RBF) and renal vascular conductance (RVC). Indomethacin pretreatment (1 mg/kg) did not alter the renal blood flow and vascular conductance responses to endothelin-1 (250 ng/kg) in conscious lambs at 1-2 or 6 weeks of age.
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