Key result
In both fetal and adult sheep, acute hypertension induced by angiotensin II was not associated with reflex bradycardia, indicating it reduces the increase in vagal tone during arterial pressure rises.
Why the study?
Does angiotensin II alter the baroreflex response to acute hypertension in conscious ewes and fetal lambs?
Does angiotensin II alter the baroreflex response to acute hypertension in conscious ewes and fetal lambs?
Angiotensin II blunts the vagally-mediated baroreflex bradycardia during acute hypertension in both adult and fetal sheep.
Authors
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No immediate implications for human hypertension care; leaves open translation of ovine baroreflex effects and requires clinical validation.
Ismay et al. (1979) studied Baroreflex response. Angiotensin II vs. Phenylephrine was evaluated on Baroreflex sensitivity (slope of the pressure-pulse interval relationship). In both fetal and adult sheep, acute hypertension induced by angiotensin II was not associated with reflex bradycardia, indicating it reduces the increase in vagal tone during arterial pressure rises.
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