Key result
Lifestyle changes and pharmacotherapy lower CV risk in older adults with metabolic syndrome and atherogenic dyslipidemia.
This review summarizes the evidence for recognizing and managing atherogenic dyslipidemia in elderly individuals with metabolic syndrome to reduce cardiovascular risk.
Supports integrated management in older MetS patients; leaves open age-specific RCTs for optimal interventions.
Summary: The proportion of people whose age exceeds 65 years is growing rapidly throughout the world and the prevalence of metabolic syndrome (MetS) is increasing among older adults. MetS had a two-fold increased risk for cardiovascular (CV) disease. Most patients with MetS exhibit atherogenic dyslipidemia, which includes elevated triglycerides (TG) and reduced high-density lipoprotein cholesterol (HDL-C). Therefore, physicians are advised to recognize the presence of dyslipidemia in elderly patients with MetS and provide appropriate therapy to reduce CV risk. Lifestyle modification is the initial step for treating dyslipidemia. For older adults with MetS who cannot attain treatment goals by lifestyle modification, pharmacological intervention is usually considered. Treating dyslipidemia in older adults with MetS requires knowledge of the benefits and adverse effects of various pharmacologic agents in the presence of possible multiple comorbidities. The purpose of this article is to review the evidence for recognition and management of atherogenic dyslipidemia in elderly individuals with MetS.
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Chen et al. (2017) conducted a review in Dyslipidemia and metabolic syndrome. Dyslipidemia management (lifestyle modification and pharmacological intervention) was evaluated. Management of atherogenic dyslipidemia in older adults with metabolic syndrome requires lifestyle modification followed by appropriate pharmacological intervention to reduce cardiovascular risk.
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