Aromatic amines are of general interest in drug metabolism and some are a health hazard, particularly as bladder carcinogens. Conditions for the biological ring- and N-oxidation of aniline and its derivatives are reviewed. The metabolism of 2-naphthylamine and aminobiphenyls and the involvement of metabolites of aromatic amines in bladder cancer is discussed.
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Gorrod et al. (1986) studied this question.
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