Patients with COPD exhibit altered locomotor muscle metaboreflex control of ventilation, likely related to type II myocyte stimuli and redox imbalance.
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Altered ventilatory control during exercise in COPD warrants caution in rehab assessment; leaves open mechanistic confirmation in prospective studies.
This study's integrative physiology approach provides evidence for a specific alteration in locomotor muscle metaboreflex control of ventilation in patients with COPD. Furthermore, molecular analyses of a skeletal muscle biopsy suggest that the amount of muscle metaboreceptor stimuli derived from type II skeletal myocytes and redox imbalance overcame a downregulation of metabolically sensitive muscle afferents.
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Aranda et al. (2024) studied this question.
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