Population
Adult rat cardiomyocytes (ARC) in long-term culture (de-/redifferentiation model)
Comparison
Three different antisense phosphorothioate… vs Control untreated ARC and random S-ODN
Design
Preclinical
Follow-up
16 days in culture
Authors
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Titin essentiality for sarcomere assembly in adult rat cardiomyocytes is hypothesis-generating; leaves open relevance to human cardiac disease.
Antisense oligonucleotide knockdown of titin in adult rat cardiomyocytes demonstrates that titin expression is essential for thick filament incorporation into sarcomeres.
Person et al. (2000) studied this question.
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