Key result
Inflammation and insulin resistance have pleiotropic actions in metabolic homeostasis and disease, with adaptive origins that contribute to their pathogenic consequences in modern obesogenic contexts.
Understanding the adaptive context of inflammation and insulin resistance provides insight into their pathogenic roles in metabolic diseases.
Highlights adaptive origins in metabolic disease; leaves open targeted therapies pending clinical validation.
Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.
No takes yet. Share an insight, caveat, or question.
Odegaard et al. (2013) conducted a review in Metabolic homeostasis and disease. Inflammation and insulin resistance have pleiotropic actions in metabolic homeostasis and disease, with adaptive origins that contribute to their pathogenic consequences in modern obesogenic contexts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: