Key result
Myocardial deoxygenation during stress is present in MYBPC3 gene carriers without left ventricular hypertrophy compared to normal controls (2% vs 15%, P<0.05), despite normal diastolic function.
Why the study?
It was unknown whether impaired myocardial oxygenation in HCM patients and gene carriers without LVH is associated with abnormalities in diastolic function or LV strain.
Observational (n=60)
Answers are grounded in this paper and cite their sources.
Myocardial deoxygenation during stress is present in MYBPC3 HCM patients even before the development of left ventricular hypertrophy or diastolic dysfunction.
AIMS: Myocardial oxygenation is impaired in hypertrophic cardiomyopathy (HCM) patients with left ventricular hypertrophy (LVH), and possibly also in HCM gene carriers without LVH. Whether these oxygenation changes are also associated with abnormalities in diastolic function or left ventricular (LV) strain are unknown. METHODS AND RESULTS: We evaluated 60 subjects: 20 MYBPC3 gene positive patients with LVH (G+LVH+), 18 MYBPC3 gene positive without LVH (G+LVH-), 11 gene negative siblings (G-), and 11 normal controls (NC). All subjects underwent 2D transthoracic echocardiography and cardiovascular magnetic resonance imaging for assessment of ventricular volumes, mass, and myocardial oxygenation at rest and adenosine stress using the blood oxygen level dependent (BOLD) technique. Maximal septal thickness was 20 mm in the G+LVH+ group, vs. 9 mm for the G+LVH- group. As expected, the G+LVH+ group had a more blunted myocardial oxygenation response to stress when compared with the G+LVH- group (-5% ± 3% vs. 2% ± 4%, P < 0.05), G- siblings (-5% ± 3% vs. 11% ± 4%, P < 0.0001) and NC (-5% ± 3% vs. 15% ± 4%, P < 0.0001). A blunted BOLD response to stress was also seen in G+LVH- subjects when compared with gene negative siblings (2% ± 4% vs. 11% ± 4%, P < 0.05) and NC (15% ± 4%, P < 0.050). G+LVH+ patients exhibited abnormal diastolic function including lower E', higher E to E' ratio and greater left atrial area compared with the G+LVH- subjects who all had normal values for these indices. CONCLUSION: Myocardial deoxygenation during stress is observed in MYBPC3 HCM patients, even in the presence of normal LV diastolic function, LV global longitudinal strain, and LV wall thickness.
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Grover et al. (2018) conducted an observational in MYBPC3-related hypertrophic cardiomyopathy (n=60). Adenosine stress cardiovascular magnetic resonance vs. Normal controls and gene negative siblings was evaluated on Myocardial oxygenation response to stress (BOLD technique) (p=<0.05). Myocardial deoxygenation during stress is present in MYBPC3 gene carriers without left ventricular hypertrophy compared to normal controls (2% vs 15%, P<0.05), despite normal diastolic function.
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