Automatic Hot Spot Detection and Segmentation in Whole Body FDG-PET Images

We present a system for automatic hot spots detection and segmentation in whole body FDG-PET images. The main contribution of our system is threefold. First, it has a novel body-section labeling module based on spatial hidden-Markov models (HMM); this allows different processing policies to be applied in different body sections. Second, the competition diffusion (CD) segmentation algorithm, which takes into account body-section information, converts the binary thresholding results to probabilistic interpretation and detects hot-spot region candidates. Third, a recursive intensity mode-seeking algorithm finds hot spot centers efficiently, and given these centers, a clinically meaningful protocol is proposed to accurately quantify hot spot volumes. Experimental results show that our system works robustly despite the large variations in clinical PET images.