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Introduction: Defence personnel are exposed to chronic occupational stressors including extreme climate, sleep deprivation, prolonged physical exertion, psychological strain, and environmental hazards. Persistent stress contributes to oxidative stress, neuroendocrine imbalance, immune dysfunction, and cognitive impairment. Brahma Rasāyana, a classical Āyurvedic Medhya Rasāyana formulation, possesses adaptogenic, antioxidant, neuroprotective, and immunomodulatory properties that may support physiological resilience. Objective: To review the adaptogenic and chemoprotective potential of Brahma Rasāyana in occupational stress and defence healthcare. Methods: A narrative literature review was conducted using PubMed/MEDLINE, Scopus, Google Scholar, ScienceDirect, AYUSH Research Portal, DHARA, and classical Āyurvedic literature. Experimental studies, clinical studies, and review articles published between 1990 and 2025 were included. Results: Brahma Rasāyana contains medicinal plants rich in polyphenols, flavonoids, tannins, alkaloids, and withanolides exhibiting antioxidant, adaptogenic, neuroprotective, anti-inflammatory, and immunomodulatory activities. Experimental and clinical evidence suggests improvement in antioxidant defence, stress tolerance, cognition, immune regulation, fatigue, and physiological adaptation. Major constituent herbs including Aśvagandhā, Guḍūcī, Āmalakī, Yaṣṭimadhu, and Śaṅkhapuṣpī contribute significantly to these effects. Conclusion: Brahma Rasāyana demonstrates promising adaptogenic and chemoprotective potential relevant to occupational stress management and integrative defence healthcare. However, further standardized clinical trials are required to establish stronger evidence regarding efficacy and safety. Keywords: Brahma Rasāyana, Adaptogen, Occupational stress, Defence healthcare, Neuroprotection
Vaidya et al. (Wed,) studied this question.