Why the study?
Do flavonoids reduce gastric damage and mucosal PAF content in rats exposed to acidified ethanol?
Population
Rats with gastric damage produced by acidified ethanol
Design
Preclinical
Authors
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Hypothesis-generating for flavonoid gastroprotection; human trials needed before any clinical relevance.
Do flavonoids reduce gastric damage and mucosal PAF content in rats exposed to acidified ethanol?
Certain flavonoids dose-dependently inhibit ethanol-induced gastric damage in rats, likely mediated by reducing endogenous platelet-activating factor.
Izzo et al. (1994) studied this question.
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