Placental Growth Factor in Acute Coronary Syndrome Patients with Non ST-Elevation

Markers of plaque instability are considered as predictors of future coronary events in patients with non ST-elevation myocardial infarction (NSTEMI) in acute coronary syndrome (ACS). The aim of this study was to determine the role of placental growth factor (PlGF) as a possible predictor of future coronary events such as non-fatal myocardial infarction or cardiac death measured at the admission and 30 days after discharge. We prospectively collected data from 102 patients admitted to the emergency department (ED) for ACS with chest pain at rest within the preceding 12 hours who were evaluated by risk factors and electrocardiogram changes (ECG). The time course of PlGF levels determined on 102 patients showed a mean value 13.21 ng/L and standard deviation 8.76 ng/L but in the sample of the 53 patients who survived after 30 days, these values decreased to 10.48 ng/L and 5.45 ng/L, respectively. Results of this study indicate a clinically useful role of PlGF in the detection of ACS and NSTEMI patients who are at a higher risk for different cardiovascular disorders within 30 days of admission.