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CommentClomifene was not associated with any increased risk of hypospadias.Several factors should be taken into account when interpreting this study.The full and independent registration of births, birth outcome, and prescriptions prevented selection bias and some types of information bias as this study was based on routinely recorded data.Any non-compliance with the use of clomifene, however, might bias the estimates of risk towards the null.
Bilukha et al. (Fri,) studied this question.