Preclinical study reveals decreased oligodendrocyte-specific gene expression in mouse models of white matter pathology, suggesting ER stress facilitates myelin degeneration.
. Moreover, ER stress-associated decreases of OL-specific gene expression were found in mature OLs from mouse models of white matter pathologies including contusive SCI, toxin-induced demyelination, and Alzheimer's disease-like neurodegeneration. Taken together, the disrupted transcriptomic fingerprint of OL lineage cells may facilitate myelin degeneration and/or dysfunction when pathological ER stress persists in OL lineage cells.
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Gao et al. (2024) studied this question.
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