Key result
Benzodiazepine initiation in adults was associated with either no increase or at most a minor increase in the risk of all-cause mortality, likely explained by residual confounding.
Why the study?
Does benzodiazepine initiation increase the risk of all cause mortality in adults?
Cohort
Does benzodiazepine initiation increase the risk of all cause mortality in adults?
Benzodiazepine initiation in adults is associated with little to no increased risk of all-cause mortality, suggesting previous reports of detrimental effects may have been overstated.
This is the authors' abstract. We don't add key points for this paper.
This large population based cohort study suggests either no increase or at most a minor increase in risk of all cause mortality associated with benzodiazepine initiation. If a detrimental effect exists, it is likely to be much smaller than previously stated and to have uncertain clinical relevance. Residual confounding likely explains at least part of the small increase in mortality risk observed in selected analyses.
Answers are grounded in this paper and cite their sources.
Benzodiazepine initiation may confer little mortality risk; leaves open whether prior signals reflect confounding and requires randomized confirmation.
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Patorno et al. (2017) conducted a cohort in Adults. Benzodiazepines was evaluated on All cause mortality. Benzodiazepine initiation in adults was associated with either no increase or at most a minor increase in the risk of all-cause mortality, likely explained by residual confounding.
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