Why the study?
How are current, maximum, and age-25 BMI associated with current levels of cardiovascular risk biomarkers in adults aged 60 years or older?
Cross-Sectional (n=4,931)
Yes
How are current, maximum, and age-25 BMI associated with current levels of cardiovascular risk biomarkers in adults aged 60 years or older?
Maximum lifetime BMI is a strong predictor of current HbA1c and HDL-cholesterol levels in older adults, independent of current BMI.
Answers are grounded in this paper and cite their sources.
Current BMI informs BP and lipid assessment in older adults; leaves open whether lifetime maximum BMI improves HbA1c prediction beyond current measures.
OBJECTIVE: There is a large literature linking current BMI to levels of cardiovascular risk biomarkers, but it is unknown whether measures of BMI earlier in the life course and maximum BMI are predictive of current levels of biomarkers. The objective of the current study was to determine how current, maximum and age-25 BMI among individuals over the age of 60 years are associated with their current levels of cardiovascular risk biomarkers. DESIGN: Cross-sectional study with retrospective recall. SETTING: Costa Rica (n 821) and the USA (n 4110). SUBJECTS: Nationally representative samples of adults aged 60 years or over. RESULTS: We used regression models to examine the relationship between multiple meaures of BMI with four established cardiovascular risk biomarkers. The most consistent predictor of current levels of systolic blood pressure, TAG and HDL-cholesterol was current BMI. However, maximum BMI was the strongest predictor of glycosylated Hb (HbA1c) and was also related to HDL-cholesterol and TAG. HbA1c was independent of current BMI. We found that these relationships are consistent between Costa Rica and the USA for HbA1c and for HDL-cholesterol. CONCLUSIONS: Current levels of cardiovascular risk biomarkers are not only the product of current levels of BMI, but also of maximum lifetime BMI, particularly for levels of HbA1c and for HDL-cholesterol. Managing maximum obtained BMI over the life course may be most critical for maintaining the healthiest levels of cardiovascular risk.
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Rehkopf et al. (2018) conducted a cross-sectional in Cardiovascular risk (n=4,931). Life-course BMI (current, age-25, maximum) was evaluated on Cardiovascular risk biomarkers (systolic blood pressure, HbA1c, TAG, HDL-cholesterol).
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