Key result
Obesity and adipose tissue interact bidirectionally with breast cancer cells to influence progression and morbidity.
Why the study?
Obesity is associated with increased breast cancer incidence and severity, but the molecular and cellular players involved in the bidirectional interaction between breast cancer and adipose cells remain incompletely understood.
This review highlights the molecular and cellular interactions between adipose tissue and breast cancer, emphasizing the role of obesity in cancer progression.
Should not change breast cancer management in obesity; leaves open whether targeting adipose-tumor interactions improves outcomes.
The incidence and severity of obesity are rising in most of the world. In addition to metabolic disorders, obesity is associated with an increase in the incidence and severity of a variety of types of cancer, including breast cancer (BC). The bidirectional interaction between BC and adipose cells has been deeply investigated, although the molecular and cellular players involved in these mechanisms are far from being fully elucidated. Here, we review the current knowledge on these interactions and describe how preclinical research might be used to clarify the effects of obesity over BC progression and morbidity, with particular attention paid to promising therapeutic interventions.
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Reggiani et al. (2021) conducted a review in Breast cancer and obesity. Obesity and adipose tissue interact bidirectionally with breast cancer cells to influence cancer progression and morbidity, highlighting potential targets for therapeutic interventions.
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