Key result
Between 30% and 60% of patients resuscitated after out-of-hospital cardiac arrest are found to have been taking antiarrhythmic drugs.
Why the study?
Do antiarrhythmic drugs cause out-of-hospital cardiac arrest in patients with ventricular tachyarrhythmia?
Observational
Do antiarrhythmic drugs cause out-of-hospital cardiac arrest in patients with ventricular tachyarrhythmia?
A significant proportion of patients resuscitated from out-of-hospital cardiac arrest were taking antiarrhythmic drugs, suggesting a potential proarrhythmic effect.
Antiarrhythmic exposure in resuscitated arrest patients may signal proarrhythmic risk; challenges consensus on empirical therapy and leaves open causal confirmation.
SUDDEN cardiac death accounts for approximately two thirds of the 600,000 annual deaths that are attributable to cardiac disease in the United States. Most of these deaths are instantaneous, occurring within seconds or minutes, and where documented, the terminal event has in most cases been a ventricular tachyarrhythmia.1 2 3 4 Earlier studies have documented the high rate of recurrence of ventricular fibrillation and sudden death in patients with ventricular tachyarrhythmia regardless of empirical antiarrhythmic drug therapy.2 , 5 , 6 In fact, between 30 and 60 per cent of patients who are resuscitated after out-of-hospital cardiac arrest are found to have been taking antiarrhythmic drugs at . . .
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Ruskin et al. (1983) conducted an observational in Out-of-hospital cardiac arrest. Antiarrhythmic drugs was evaluated. Between 30% and 60% of patients resuscitated after out-of-hospital cardiac arrest are found to have been taking antiarrhythmic drugs.
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