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November 24, 1983New England Journal of Medicine

Antiarrhythmic Drugs: a Possible Cause of Out-of-Hospital Cardiac Arrest

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Why the study?

Do antiarrhythmic drugs cause out-of-hospital cardiac arrest in patients with ventricular tachyarrhythmia?

Population

Patients resuscitated after out-of-hospital cardiac arrest

Design

Other

Key result

Between 30% and 60% of patients resuscitated after out-of-hospital cardiac arrest are found to have been taking antiarrhythmic drugs.

Authors

JRJeremy N. RuskinBMBrian A. McGovernHGHasan Garan

Discussion

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Overview

Antiarrhythmic exposure in resuscitated arrest patients may signal proarrhythmic risk; challenges consensus on empirical therapy and leaves open causal confirmation.

Study Design

Type

Observational

Structured PICO

Do antiarrhythmic drugs cause out-of-hospital cardiac arrest in patients with ventricular tachyarrhythmia?

P
Population
Patients resuscitated after out-of-hospital cardiac arrest
I
Intervention
Antiarrhythmic drugs
O
Outcome
Out-of-hospital cardiac arresthard clinical

A significant proportion of patients resuscitated from out-of-hospital cardiac arrest were taking antiarrhythmic drugs, suggesting a potential proarrhythmic effect.

Cite This Study

Ruskin et al. (1983) conducted an observational in Out-of-hospital cardiac arrest. Antiarrhythmic drugs was evaluated. Between 30% and 60% of patients resuscitated after out-of-hospital cardiac arrest are found to have been taking antiarrhythmic drugs.

synapsesocial.com/papers/6a10d0c98102eb4b66ee7751https://doi.org/10.1056/nejm198311243092107
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