Why the study?
Is symptomatic diabetic polyneuropathy associated with increased activity of the hypothalamic-pituitary-adrenal axis?
Is symptomatic diabetic polyneuropathy associated with increased activity of the hypothalamic-pituitary-adrenal axis?
Diabetic neuropathy is associated with a specific and persistent increase in the activity of the hypothalamic-pituitary-adrenal axis, independent of diabetes type or glycemic control.
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Symptomatic diabetic polyneuropathy may involve HPA-axis hyperactivity; hypothesis-generating and should not yet change practice.
Tsigos et al. (1993) studied this question.
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