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Across biology, structural hierarchy converts bottom-up self-assembly into macroscopic function, yielding emergent mechanical, transport, and optical behaviors. Liquid crystals (LCs) are uniquely positioned in this realm by coupling fluidity with long-range orientational order, providing a physics-grounded toolkit: director fields, elasticity, chirality, and topological defects for sculpting free-energy landscapes that organize matter with molecular precision. Crucially, these soft blueprints can be transduced into solids, preserving order and programming function, which offers a route to nanofabrication that can surpass conventional top-down manufacturing. Here, we formulate LC-physics design rules that translate equilibrium and far-from-equilibrium mesophase phenomena into manufacturing with programmable nanoscale order. We emphasize how elasticity and anchoring set length scales; how defect networks act as programmable sites for trapping, nucleation, and guided growth; and how chirality and curvature encode photonic and transport responses. We survey advances in LC-based assembly spanning polymers, colloids, biomolecules, perovskites, and inorganic hybrids, from mesophase and boundary design to functionalization and property activation. We also identify a bioinspired frontier in which external fields and confinement can inscribe nonequilibrium LC textures. By identifying current challenges and future opportunities, we highlight how LC physics insights could revolutionize scalable nanofabrication with molecular order precision.
Money et al. (Wed,) studied this question.