Key result
Circumferential LV strain measured by DENSE cardiac MRI provided incremental prognostic benefit over infarct size for predicting MACE after acute STEMI (HR 1.3; P<.01).
Why the study?
The study was conducted to investigate the prognostic value of circumferential left ventricular strain measured by cardiac MRI for predicting major adverse cardiac events following acute STEMI.
Does circumferential LV strain measured by cardiac MRI predict major adverse cardiac events following an acute STEMI?
Cohort (n=259)
Blinded outcome assessment
Does circumferential LV strain measured by cardiac MRI predict major adverse cardiac events following an acute STEMI?
Effect estimate: HR 1.3
p-value: p=< .01
Circumferential LV strain measured by DENSE cardiac MRI provides independent and incremental prognostic value over infarct size for predicting MACE after acute STEMI.
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May refine post-STEMI risk stratification beyond infarct size; leaves open whether DENSE strain alters management or outcomes.
Mangion et al. (2018) conducted a cohort in Acute ST-segment-elevation myocardial infarction (STEMI) (n=259). Circumferential left ventricular strain measured by cardiac MRI vs. Infarct size and extent of microvascular obstruction was evaluated on Major adverse cardiac events (MACE) (HR 1.3, p=< .01). Circumferential LV strain measured by DENSE cardiac MRI provided incremental prognostic benefit over infarct size for predicting MACE after acute STEMI (HR 1.3; P<.01).
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