Simulation study evaluates multi-treatment trial performance under model misspecification in clinical survival settings, highlighting the robustness of adaptive designs.
Multi-treatment two stage adaptive design for survival responses is generally developed under different assumptions. In this work, we explore the performance of such a design when the assumptions are violated. As a choice of design, we consider a specific design of Bhattacharya and Shome (2019), which uses random censoring, exponential response, Koziol-Green model (Koziol and Green, 1976), etc. Several ethical and inferential criteria of the design are studied under model misspecification for different parameter configurations as well as for a data arising from a real clinical trial. IJSS, Vol. 24(2) Special, December, 2024, pp 67-79
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Das et al. (2024) studied this question.
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