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The first two SGLT2 inhibitors approved in Australia, dapagliflozin and canagliflozin, have high bioavailability. They have a half-life of about 12 hours and are taken once a day. Dapagliflozin can be taken with or without food, while it is recommended that canagliflozin is taken before the first meal of the day. Both drugs are highly protein bound in plasma and are metabolised in the liver via glucuronidation.
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Thynne et al. (2013) studied this question.
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