White-coat hypertension was not significantly associated with an increased risk of stroke compared to normotension overall (HR 1.15; 95% CI 0.61-2.16; P=0.66), though risk tended to increase long-term.
Cohort (n=5,955)
Yes
Does white-coat hypertension increase the risk of first stroke compared to normotension in untreated subjects?
White-coat hypertension is not associated with an increased overall risk of stroke over a median 5.4 years, but risk may increase after 6 years of follow-up, suggesting it is not entirely benign long-term.
Effect estimate: HR 1.15 (95% CI 0.61 to 2.16)
Absolute Event Rate: 0.59% vs 0.35%
p-value: p=0.66
White-coat hypertension (WCH) has been associated with a low risk for stroke, but long-term data are scanty. We analyzed individual data from 4 prospective cohort studies from the United States, Italy, and Japan that used comparable methodology for 24-hour noninvasive ambulatory blood pressure monitoring (ABPM). Overall, 4406 subjects with essential hypertension and 1549 healthy normotensive controls who were untreated at the time of initial ABPM were followed for a median of 5.4 years up to censoring or occurrence of a first stroke. At entry, mean age of subjects was 56 years (range 18 to 97). Prevalence of WCH was 9%. During follow-up, there were 213 new cases of stroke. Stroke rate (x100 person years) was 0.35 in the normotensive group, 0.59 in the WCH group, and 0.65 in the group with ambulatory hypertension. In a multivariate analysis, the adjusted hazard ratio for stroke was 1.15 (95% confidence interval CI, 0.61 to 2.16) in the WCH group (P=0.66) and 2.01 (95% CI, 1.31 to 3.08) in the ambulatory hypertension group (P=0.001) compared with the normotensive group. After the sixth year of follow-up, the incidence of stroke tended to increase in the WCH group, and the corresponding hazard curve crossed that of the ambulatory hypertension group by the ninth year of follow-up. In conclusion, WCH was not associated with a definitely increased risk of stroke during the total follow-up period. However, WCH might not be a benign condition for stroke in the long term.
Verdecchia et al. (2005) conducted a cohort in White-coat hypertension (n=5,955). White-coat hypertension vs. Normotension was evaluated on First stroke (HR 1.15, 95% CI 0.61 to 2.16, p=0.66). White-coat hypertension was not significantly associated with an increased risk of stroke compared to normotension overall (HR 1.15; 95% CI 0.61-2.16; P=0.66), though risk tended to increase long-term.