Progress Born From a Legacy of Collaboration

This Special Series issue of Journal of Clinical Oncology highlights collaborative efforts that have contributed to the remarkable progress achieved in advancing survival for pediatric cancers. These efforts have involved collaborations across a variety of medical subspecialties, institutions, and national and international cooperative study groups and, most importantly, collaborations among clinicians, scientists, and patients and their families. Unique to the pediatric cancer experience is a high level of participation in clinical trials that has been instrumental in establishing effective therapies for virtually all types of pediatric cancers; characterizing acute, long-term, and late-onset toxicities of therapy; refining treatment approaches adapted to the biologic characteristics of the disease; and, in recent decades, modifying therapy to prevent treatment-related adverse effects. Particularly featured within this series are innovative and genomic discoveries that have guided risk-adapted stratification of therapy and use of targeted therapy providing real prospects for precision medicine.