Key result
The A1166C mutation in the angiotensin II type 1 receptor gene was not associated with primary hypertension, though a trend toward decreased prevalence was seen in late-onset hypertension.
Why the study?
Is the A1166C polymorphism in the angiotensin II type 1 (AT1) receptor gene associated with primary hypertension?
Case-Control (n=586)
Is the A1166C polymorphism in the angiotensin II type 1 (AT1) receptor gene associated with primary hypertension?
Answers are grounded in this paper and cite their sources.
The A1166C polymorphism in the AT1 receptor gene does not appear to be associated with primary hypertension, challenging previous reports.
BACKGROUND: A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension. OBJECTIVE: To determine whether this observation could be confirmed with a different population sample. DESIGN: We examined 414 individuals with primary hypertension and 172 normotensive controls. METHODS: The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction. CONCLUSIONS: We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.
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Schmidt et al. (1997) conducted a case-control in Primary hypertension (n=586). A1166C mutation in the AT1 receptor gene vs. Normotensive controls was evaluated on Association of the AT1 receptor polymorphism with hypertension. The A1166C mutation in the angiotensin II type 1 receptor gene was not associated with primary hypertension, though a trend toward decreased prevalence was seen in late-onset hypertension.
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