The A1166C mutation in the angiotensin II type 1 receptor gene was not associated with primary hypertension, though a trend toward decreased prevalence was seen in late-onset hypertension.
Case-Control (n=586)
Is the A1166C polymorphism in the angiotensin II type 1 (AT1) receptor gene associated with primary hypertension?
The A1166C polymorphism in the AT1 receptor gene does not appear to be associated with primary hypertension, challenging previous reports.
BACKGROUND: A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension. OBJECTIVE: To determine whether this observation could be confirmed with a different population sample. DESIGN: We examined 414 individuals with primary hypertension and 172 normotensive controls. METHODS: The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction. CONCLUSIONS: We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.
Schmidt et al. (Mon,) conducted a case-control in Primary hypertension (n=586). A1166C mutation in the AT1 receptor gene vs. Normotensive controls was evaluated on Association of the AT1 receptor polymorphism with hypertension. The A1166C mutation in the angiotensin II type 1 receptor gene was not associated with primary hypertension, though a trend toward decreased prevalence was seen in late-onset hypertension.