Key result
Chicken CD44 knockdown reduces infectious bursal disease virus replication by ~92% in DT40 cells.
Why the study?
Infectious bursal disease virus causes severe immunosuppressive disease in chickens, but the specific mechanism of how it invades host cells was not very clear.
Answers are grounded in this paper and cite their sources.
Chicken CD44 acts as a novel cellular receptor for Infectious Bursal Disease Virus, promoting its binding and entry into B lymphocytes.
Infectious bursal disease virus (IBDV) causes severe immunosuppressive disease in chickens, inducing huge economic losses for the poultry industry. However, the specific mechanism of IBDV invading host cells of IBDV was not very clear. This study shed light on which cellular protein component IBDV is used to bind and/or enter B lymphocytes. The results of our study revealed that chCD44 could promote both the binding and entry ability of IBDV in B lymphocytes, acting as a cellular receptor for IBDV. Besides, this is the first report about chicken CD44 function in viral replication. Our study impacts the understanding of the IBDV binding and entry process and sets the stage for further elucidation of the infection mechanism of IBDV.
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Liu et al. (2022) studied Infectious bursal disease virus (IBDV) infection (n=36). Chicken CD44 knockdown vs. shRNA control was evaluated on IBDV replication (viral copy number) at 48 hours post-infection (92% decrease, p=<0.05). Knockdown of chicken CD44 significantly reduced infectious bursal disease virus replication by 92% at 48 hours post-infection in DT40 cells.
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