Key result
Children with chronic kidney disease had significantly increased abdominal aortic stiffness index (3.1 vs 2.6, p=0.004) and decreased distensibility and strain compared to healthy controls.
Why the study?
To evaluate cardiovascular risks, aortic elasticity parameters, carotid intima thickness, and the effect of hydration status on vascular functions in children with chronic kidney disease.
Does chronic kidney disease and hydration status affect aortic elasticity and vascular function in children?
Case-Control (n=69)
No
Does chronic kidney disease and hydration status affect aortic elasticity and vascular function in children?
Absolute Event Rate: 3.1% vs 2.6%
p-value: p=0.004
Children with chronic kidney disease demonstrate early adverse vascular wall changes, including decreased aortic distensibility and increased stiffness, alongside significant over-hydration.
May signal early vascular changes in pediatric CKD; leaves open hydration effects on aortic function.
Objective: We aimed to evaluate cardiovascular risks and influencing factors by measuring aortic elasticity parameters and carotid intima thickness in children with cronic kidney disease (CKD), and also evaluated the hydration status of patients with bioimpedance spectroscopy (BIS) measurements and investigated the effect of hydration status on vascular functions. Patients and Methods: The study group included an average of 13.3 ± 3.7 years (16 girls and 22 boys, 38 CKD patients), control group on average 12.1 ± 2.9 (16 girls and 15 boys, 31 healthy children). Systolic and diastolic diameters of the aortic annulus and aorta at each level were obtained; z-scores, aortic strain, distensibility, stiffness index were calculated. Carotid intima-media thickness and flow – mediated dilatation were studied. Bioimpedance spectroscopy was performed to all patients. Results: Interventricular septum and left atrial (p=0.002, p=0.013), sinus valsalva and sinotubular junction z scores (p=0.009, p=0.012) were found to be higher and distensibility and strain decreased, stiffness index increased in the abdominal aorta of patients with CKD (p=0.007, p=0.002, p=0.004). Patients with CKD had statistically significant over-hydration. Conclusion: Vascular wall changes that affect the elastic properties of the aortic wall begin to develop in childhood in patients with CKD.
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Sarısoy et al. (2024) conducted a case-control in Chronic kidney disease (n=69). Chronic kidney disease vs. Healthy controls was evaluated on Abdominal aorta stiffness index (p=0.004). Children with chronic kidney disease had significantly increased abdominal aortic stiffness index (3.1 vs 2.6, p=0.004) and decreased distensibility and strain compared to healthy controls.
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