What is the clinical evidence from this study?

Study design: Observational. Population: Aneurysmal subarachnoid hemorrhage (n=358). Intervention: 1990-1998 time period vs. 1980-1989 time period. Primary outcome: Age- and sex-adjusted incidence rate per 100,000/y.

July 1, 2001StrokeOpen Access

Trends in Incidence and Case Fatality Rates of Aneurysmal Subarachnoid Hemorrhage in Izumo City, Japan, Between 1980–1989 and 1990–1998

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Key result

The age- and sex-adjusted incidence rate of aneurysmal SAH remained stable at 23 per 100,000/y between 1980-1989 and 1990-1998, with similar overall case fatality rates (39% vs 36%).

Key Points

To evaluate long-term trends in the incidence and case fatality rates of aneurysmal subarachnoid hemorrhage across two consecutive time periods in an aging population.
Analyzed and compared cases of aneurysmal subarachnoid hemorrhage diagnosed during 1980–1989 (N=170) and 1990–1998 (N=188) in Izumo City, Japan.
Calculated crude and age- and sex-adjusted incidence rates using 1995 Japanese standard population statistics and assessed 3-month case fatality rates stratified by age.
The age- and sex-adjusted incidence rate remained stable at 23 per 100,000/year in 1980–1989 and 23 per 100,000/year in 1990–1998 (crude rates: 21 vs 25 per 100,000/year), while the proportion of patients aged ≥80 years rose from 5% (n=8) to 18% (n=33, P<0.001).
The 3-month case fatality rate for patients aged ≤79 years decreased from 38% to 26% (P=0.021), but high fatality rates in patients aged ≥80 years (63% and 79%) kept overall case fatality rates similar between periods (39% vs 36%).

Study Design

Type

Observational (n=358)

Structured PICO

Population

358 patients with aneurysmal subarachnoid hemorrhage (SAH) in Izumo City, Japan (170 diagnosed during 1980-1989 and 188 during 1990-1998)

Outcome

Incidence rate and 3-month case fatality rate of aneurysmal SAHhard clinical

Main Result

Absolute Event Rate: 23% vs 23%

Despite improvements in survival for younger patients, the overall case fatality rate of aneurysmal SAH has not decreased due to the aging population and higher proportion of very elderly patients.

Discussion

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Implication

Aging demographics offset younger survival gains in aneurysmal SAH; leaves open whether targeted elderly strategies can lower overall fatality.

Cite This Study

Tetsuji Inagawa (2001) conducted an observational in Aneurysmal subarachnoid hemorrhage (n=358). 1990-1998 time period vs. 1980-1989 time period was evaluated on Age- and sex-adjusted incidence rate per 100,000/y. The age- and sex-adjusted incidence rate of aneurysmal SAH remained stable at 23 per 100,000/y between 1980-1989 and 1990-1998, with similar overall case fatality rates (39% vs 36%).

synapsesocial.com/papers/6a10f5dd326831f8a26494da https://doi.org/10.1161/01.str.32.7.1499

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Implication

Aging demographics offset younger survival gains in aneurysmal SAH; leaves open whether targeted elderly strategies can lower overall fatality.

Trends in Incidence and Case Fatality Rates of Aneurysmal Subarachnoid Hemorrhage in Izumo City, Japan, Between 1980–1989 and 1990–1998

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Trends in Incidence and Case Fatality Rates of Aneurysmal Subarachnoid Hemorrhage in Izumo City, Japan, Between 1980–1989 and 1990–1998

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

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