A self-reported history of depression was associated with an increased risk of Alzheimer disease at 2 years (OR 1.9; 95% CI 1.0-3.3) and 5 years (OR 1.6; 95% CI 0.9-2.7) of follow-up.
Cohort (n=3,346)
No
Does a history of depression increase the risk of Alzheimer disease in older adults?
Self-reported history of depression is associated with an increased risk of Alzheimer disease in older adults.
Effect estimate: OR 1.9 (95% CI 1.0-3.3)
BACKGROUND: Several epidemiologic studies have examined depression as a risk factor for Alzheimer disease with conflicting results. Most studies relied on self-reported depression, but the agreement between self-reported depression and clinical diagnosis has been reported to be weak, thereby diluting the association. METHODS: A population-based cohort in Odense, Denmark, of 3346 persons age 65-84 years was examined at baseline (1992-1994) and after 2 years (1994-1996) and 5 years (1997-1999). History of depression was collected at baseline as self-report. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Persons with a history of depression had an increased risk of Alzheimer disease both at baseline (OR = 1.7; CI = 1.0-2.7) and at follow up (at 2 years, 1.9 1.0-3.3 and at 5 years, 1.6 0.9-2.7). CONCLUSIONS: Depression was associated with an increased risk of Alzheimer disease. The odds ratios were lower than generally reported from follow-up studies and are similar to cross-sectional studies.
Andersen et al. (Wed,) conducted a cohort in Alzheimer disease (n=3,346). History of depression vs. No history of depression was evaluated on Alzheimer disease (OR 1.9, 95% CI 1.0-3.3). A self-reported history of depression was associated with an increased risk of Alzheimer disease at 2 years (OR 1.9; 95% CI 1.0-3.3) and 5 years (OR 1.6; 95% CI 0.9-2.7) of follow-up.