Key result
Modeling reveals distinct age-related cardiovascular, respiratory, and nervous system responses to exhaustive exercise in youth.
Why the study?
Understanding complete cardiopulmonary function during exhaustive exercise is limited by invasive measurement techniques.
How do cardiopulmonary function and oxidative stress during exhaustive exercise differ across age cohorts 6-11 and 11-18?
How do cardiopulmonary function and oxidative stress during exhaustive exercise differ across age cohorts 6-11 and 11-18?
A whole-body physiology model reveals distinct age-related cardiopulmonary and nervous system perturbations during exhaustive exercise in children and adolescents.
Hypothesis-generating for age-specific exercise responses in youth; leaves open prospective validation before clinical translation.
Background: There is a limitation in understanding complete cardiopulmonary function during moments of exhaustive exercise due to invasive measurement techniques. We asked how cardiopulmonary function is perturbed during times of exercise in different age cohorts: 6–11 and 11–18. We sought to broadly analyze how age and oxidative stress during exercise differ across age cohorts. Methods: We present a whole-body physiology model that connects the nervous, cardiovascular, respiratory, and oxygen transport and binding systems. We connect these models using a lumped parameter representation of the cardiovascular and respiratory systems. Results: we observe distinct age-related difference in physiological response to exercise. These responses consist of respiratory, cardiovascular, and nervous system perturbations that are distinct across these age groups.
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Baird et al. (2025) studied Cardiopulmonary function during exercise. Whole-body physiology model was evaluated on Physiological response to exercise. A whole-body physiology model demonstrated distinct age-related differences in respiratory, cardiovascular, and nervous system responses to exhaustive exercise between cohorts aged 6-11 and 11-18.
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