Key result
PCOS is linked to higher fasting insulin and HOMA-IR that correlate with elevated serum prolactin.
Why the study?
Polycystic ovarian syndrome is linked to insulin resistance and cardiovascular risk, and prolactin is a lipogenic and diabetogenic factor affecting fuel metabolism.
Case-Control (n=100)
p-value: p=<0.001
Serum prolactin and insulin resistance are significantly elevated in women with PCOS, suggesting a potential correlation between prolactin levels and dysglycemia in this population.
Association of prolactin with insulin resistance in PCOS is hypothesis-generating; prospective studies needed to assess causality and therapeutic implications.
Background: Polycystic ovarian syndrome has been one of a major public health problem. It causes multifactorial in etiology such as menstrual dysfunction, hyperandrogenism, hirsutism, insulin resistance, dyslipidemia and obesity which increased risk of diabetes mellitus and cardiovascular disease. Prolactin has been reported as a potent lipogenic and diabetogenic factor, that affecting energy balance and fuel metabolism. The present study was designed to assess serum prolactin and insulin resistance in PCOS women and to compare them with healthy women as controls. Material And Methods: A comparative study including 50 women newly diagnosed as PCOS and 50 healthy women as controls was conducted. The age group for the study was 18-35 years. Fasting blood samples were drawn to assess serum prolactin, serum insulin and fasting blood sugar. Insulin resistance was calculated by homeostasis model assessment. Results: A signicant increase in fasting serum insulin (p<0.001) and HOMA – IR (p<0.001) were found in patients with PCOS in comparison with controls. Prolactin and FPG were found elevated in the PCOS women and were statistically signicant. Conclusions: The current study provides further evidence that signicantly higher fasting insulin and HOMA in PCOS group indicates presence of IR. IR in PCOS group may have a potential role in the prediction of dysglycemic disease in women with PCOS. This study found signicant correlation between serum prolactin and serum insulin
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Basu et al. (2021) conducted a case-control in Polycystic ovarian syndrome (PCOS) (n=100). Polycystic ovarian syndrome (PCOS) vs. Healthy women was evaluated on Fasting serum insulin and HOMA-IR (p=<0.001). Women with PCOS had significantly higher fasting serum insulin (p<0.001), HOMA-IR (p<0.001), and serum prolactin compared to healthy controls, with a significant correlation between prolactin and insulin.
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