Alternative mimetics: Short cyclic hexapeptides (see picture; blue N, red O, white H, gray C) can be effective for oligosaccharide mimicry. The individual contributions of cyclization, amino acid stereochemistry, turn position, and side-chain functionality to the glycomimetic properties of the peptides were identified. Two peptides proved to be high-affinity ligands for the 412 antibody and also showed enhanced functional activity as HNK-1 mimetics.
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Bächle et al. (2006) studied this question.
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