Key result
Early administration of aspirin in AMI patients admitted from post-acute/long-term care settings was associated with reduced 30-day mortality (OR 0.50; 95% CI 0.43-0.58).
Why the study?
Does early administration of aspirin and reperfusion improve 30-day mortality in patients hospitalized with AMI from PAC/LTC versus community settings?
Observational (n=128,183)
Yes
Does early administration of aspirin and reperfusion improve 30-day mortality in patients hospitalized with AMI from PAC/LTC versus community settings?
Patients admitted with AMI from post-acute and long-term care settings are less likely to receive guideline-concordant care like aspirin and reperfusion, despite these treatments being associated with improved 30-day survival.
BACKGROUND: Previous studies have examined differences in care for acute myocardial infarction (AMI) according to patient characteristics such as age, gender, or insurance, but little attention has been given to whether admission source is related to guideline adherence. OBJECTIVE: To investigate: (1) the use of aspirin and reperfusion in the care of post-acute/long-term care (PAC/LTC) patients who are hospitalized for AMI, and (2) 30-day mortality associated with these treatments. DESIGN: Secondary examination of data from the Cooperative Cardiovascular Project (CCP) national baseline data. SETTING: A total of 4013 U.S. hospitals. SUBJECTS: Patients hospitalized with a confirmed AMI admitted from PAC/LTC (n = 8151) or community-dwelling (n = 120,032) settings. MEASUREMENTS: Early administration of aspirin and reperfusion via either thrombolysis or percutaneous intervention. RESULTS: PAC/LTC patients were less likely to receive treatment for AMI, even after adjustment for multiple variables associated with treatment choice. Differences persisted with additional econometric adjustment using seemingly-unrelated regression. Multivariable logistic regression results indicated that aspirin was related to improved 30-day survival for both PAC/LTC and community admissions (odds ratio [OR], 0.50; 95% confidence interval [CI], 0.43-0.58 for PAC/LTC, and OR, 0.57; 95% CI, 0.54-0.60 for community). Reperfusion was associated with higher ORs for mortality for eligible patients admitted from community setting (OR, 1.24; 95% CI, 1.13-1.35), but ideally-eligible candidates had lower ORs for mortality (OR, 0.58; 95% CI, 0.35-0.95 for PAC/LTC, and OR, 0.74; 95% CI, 0.68-0.81 for community). CONCLUSIONS: Patients transferred from PAC/LTC settings were less likely to receive early treatment for AMI than other patients. Future trials should inform which guidelines are applicable to PAC/LTC patients.
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Radcliff et al. (2010) conducted an observational in Acute myocardial infarction (AMI) (n=128,183). Early administration of aspirin vs. No early aspirin administration was evaluated on 30-day mortality (OR 0.50, 95% CI 0.43-0.58). Early administration of aspirin in AMI patients admitted from post-acute/long-term care settings was associated with reduced 30-day mortality (OR 0.50; 95% CI 0.43-0.58).
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