Key result
HARU-1 sheet-type EEG accurately detects increased forehead alpha waves during closed-eye versus open-eye conditions.
Why the study?
There is an urgent need to establish an objective biomarker of brain activity without invasive or behavioral restrictions for individuals undergoing psychiatric rehabilitation.
Can the sheet-type EEG device HARU-1 detect the "Berger effect" in healthy subjects?
Observational (n=20)
No
Can the sheet-type EEG device HARU-1 detect the "Berger effect" in healthy subjects?
p-value: p=<0.001
The sheet-type EEG device HARU-1 accurately measures the Berger effect in the forehead region, suggesting potential utility for objective brain activity monitoring in psychiatric rehabilitation.
For individuals undergoing psychiatric rehabilitation, there is an urgent need to establish an objective biomarker of brain activity without invasive or behavioral restrictions. To investigate an objective index for potential psychiatric rehabilitation assessment and intervention strategies in the future, we tried to detect the "Berger effect", the alpha EEG reactivity to eyes opening, and to verify the suitability of a sheet-type electroencephalography (EEG) device, HARU-1. We measured EEG of 20 healthy young to middle-aged subjects using HARU-1 from the forehead area during resting closed-eye and open-eye conditions. Fast Fourier transform and time-frequency analysis were then performed on the data from all subjects in the resting closed-eye and resting open-eye conditions. Statistical analysis found that the reference electrode derivation method showed a significant increase in alpha waves and a significant decrease in beta and gamma waves in the three forehead channels of Fp1, Fp2 and AFz during the resting closed eye condition compared to the resting open eye condition. In the bipolar derivation method, all Fp1-AFz, Fp2-Fp1 and AFz-Fp2 showed a significant decrease in the β and γ bands at approximately 13-50 Hz. These results demonstrated that HARU-1 accurately measured the "Berger effect" in the forehead region, suggesting that HARU-1 may be useful in detecting objective biomarkers of brain activity during psychiatric rehabilitation.
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Shiroma et al. (2025) conducted an observational in Healthy subjects (n=20). HARU-1 sheet-type EEG device (resting closed-eye condition) vs. Resting open-eye condition was evaluated on Alpha wave power in forehead channels (AFz, Fp1, Fp2) (p=<0.001). The HARU-1 sheet-type EEG device accurately detected the Berger effect, demonstrating a significant increase in alpha wave activity in the forehead region during resting closed-eye compared to open-eye conditions (p<0.001).
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